“M!Shepard’s female romances are pregnant after ME2, but they don’t tell him in fear he won’t want to keep the baby. The same goes for Fem!Shepard’s male romances, with her as the pregnant one (of course). With Fem!Shep and Liara, it could be either way depending on the player’s choice.”
Submitted by amon—ster.
I’ve come across some pretty “out there” headcanons and I try to stay out of it, because, hey, somebody else’s headcanons are none of my business. And I’m positive somebody’s already beat me to the punch on this one but, sweetie, humans can’t cross-breed with aliens unless they’re asari and even then, the asari chooses to become pregnant. It isn’t accidental.
Also, Miranda is barren and, because Shepard has similar genetic modifications post-resurrection, she might be barren too. I think of it has one of the many drawbacks of being a superhuman capable of living well beyond the average human lifespan (around 150 years in ME).